Two thoughts: The best startups are masters of asymmetric warfare -- they don't fight on the battlefield the incumbent selects. And, users often understand their problems well but are horrible at suggesting features to solve these problems.
The Twenty Minute VC (20VC): Venture Capital | Startup Funding | The Pitch: 20VC: Box's Aaron Levie on Why Founders Cannot Hedge Their Bets, The 2 Categories of Wrong Decision and How To Avoid Them & The Biggest Dangers of Being Over-Funded as a Startup