the overcrowding effect has the power of increasing the local concentration by an order of magnitude with respect to the bulk. Reaction outside does not take place because of the excessive dilution,

the incapability of computationalism to account for the central role of the body in cognitive processes.

the system and its environment must then be located in the intricate history of their structural transformations, where each one selects the trajectory of the other one.

Life is the mode of existence of protein bodies, the essential element of which consists in continual metabolic interchange with the natural environment outside them,

micelles are thermodynamically stable systems, vesicles are not.

kinetic control, possibly mediated by catalysts, may be another chemical determinant of the prebiotic evolution,

tides, which may increase the solute local concentration when withdrawing, with a possible localized scenario such as hydrothermal pools or small lagoons, or even coastal lakes.

The boundary of the system must be “of its own making,”

point is that theories involving the organization of complex, small-molecule metabolic cycles, such as the reductive citric-acid cycle on mineral surfaces, have to make unreasonable assumptions about the catalytic properties of minerals and the ability of minerals to organize sequences of disparate reactions.