
The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets

One of them was an enzyme, appropriately anointed Dicer,
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
Because almost all enzymes are proteins and have no RNA, they are unfazed by RNase treatment.
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
RNA, conversely, doesn’t have one shape but millions of possible shapes.
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
Remarkably, about half of all useful antibiotics target bacterial ribosomes.
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
unusual set of Tetrahymena genes that existed as minichromosomes, each less than a thousandth the size of the smallest human chromosome. These individual DNA molecules harbored Tetrahymena’s ribosomal RNA genes.
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
enzyme-catalyzed reactions were extraordinarily specific;
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
Scientists discovered a suite of previously undetected
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
there were six varieties, and because they were rich in uracil (the letter U in the RNA alphabet), they had been dubbed U1 through U6.
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
Telomerase is produced by the rapidly growing cells in the human embryo, but this action gets turned off in most of our cells by the time we’re born. The few key exceptions include stem cells—