A new study from Nature shows that both painkillers, especially when used together, can contribute to antibiotic resistance in the setting of a bacterial infection. So they may be helping an acute fever but potentially make infection worse in the future. The finding comes amid decreasing options we have to treat antibiotic-resistant organisms

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A recent study from August 2025 in Nature looked at nine different medications: acetaminophen, ibuprofen, diclofenac, furosemide, atorvastatin, metformin, pseudoephedrine, temazepam, and tramadol. In the presence of ciprofloxacin, a commonly used antibiotic, ibuprofen and acetaminophen increased the mutation rates of E. coli, a common human

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