“Histologically, endometriotic lesions are quite diverse. Clement (2007) first emphasized the presence of both epithelial and stromal cell types, while Greaves et al. (2017) showed how this tissue recruits immune cells that create a chronic inflammatory environment. Forster et al. (2019) expanded on this by linking vascularization to lesion growth,... See more

ndometriosis lesions are complex multicellular tissue deposits composed of endometrial-like stromal cells with or without epithelial cells or glands embedded within a microenvironment of extracellular matrix, fibrosis, scarring, and sometimes haemorrhage (Clement, 2007; Vigano et al. , 2018). Additionally, lesions are infiltrated by blood vessels,... See more

The overwhelming prevalence of endometriosis and the unknown aeteology highlight the need for a better understanding of the basic biology of endometriosis formation and persistence to enable subsequent identification of targets for effective therapies for endometriosis.