Hey Brad,

Big picture on Ozempic... it works... Long term... maybe not so much.

It’s the drug that’s everywhere right now — and while it does work for appetite suppression and weight loss, the long-term picture isn’t as simple as the headlines make it out to be.

Here’s the deal: Ozempic (semaglutide) is a GLP-1 receptor agonist. GLP-1 is a hormone secreted from the L-cells of the intestine after eating that:

Slows gastric emptying by reducing stomach contractions, so food stays in the stomach longer and satiety signals extend.
Enhances glucose-dependent insulin secretion from the pancreas, helping manage blood sugar spikes.
Suppresses glucagon release, lowering hepatic glucose output.
Activates receptors in the hypothalamus that directly reduce hunger signals.

Sounds great, right? But here’s the kicker — you’re essentially outsourcing your appetite control to a drug.

When you stop taking it, studies show most people regain much of the lost weight because the underlying appetite regulation wasn’t fixed.

Add in side effects like nausea, delayed nutrient absorption (fat-soluble vitamins can be compromised), GI distress, and the risk of losing lean mass if protein isn’t prioritized — and it’s clear Ozempic isn’t the “easy button” it’s marketed as.

So what’s the alternative? Instead of outsourcing appetite regulation, you can train your body to stimulate GLP-1 and other satiety hormones naturally:

Protein-first approach: Aiming for 30–40g of high-quality protein per meal boosts thermogenesis and strongly stimulates GLP-1 and peptide YY while suppressing ghrelin (the hunger hormone). The amino acid leucine in particular signals the hypothalamus to reduce appetite.

Fiber + resistant starch: Fermentable fibers and resistant starches are converted by gut microbes into short-chain fatty acids like butyrate and propionate. These directly bind to free fatty acid receptors (FFAR2/3) on L-cells, increasing GLP-1 and PYY secretion.

Allulose (the “rare sugar”): Unlike glucose or fructose, allulose blunts post-meal glycemic spikes and directly stimulates GLP-1 release. The human data shows it reduces appetite while improving insulin sensitivity.

This is probably the most cutting edge way to mimic ozempic that we have yet. Allulose directly acts upon GLP-1 stimulators in the body, making it the most potent natural stimulator that we have uncovered yet.

Studies are demonstrating that just 5-10g of allulose can have a potent appetite suppressing effect for hours.

When I take 5-10g of allulose, I don't have an appetite for about 4-5 hours. It is wild and at first I couldn't believe that it actually worked. But the science doesn't lie (nor does my anecdotal experience).

I've talked about ways to use Allulose before, like RxSugar's brownies, gummies, etc, but one of the most potent and inexpensive ways is just to use their stick packs that are 10g of allulose all with unique and tasty flavors.

It's almost like a candy powder that you just pour right into your mouth or mix into a tasty drink. But the cool thing is that because it is pure allulose, it hits your system fast. So it is almost instant appetite suppressant.

Best Part? It's 50% Off right now... Yep, legit using this link, a huge 50% off their already great price.

Try it here for 50% Off RxSugar GLP-1 Stimulating stick packs

If there is one thing that you can do (besides eating a healthy diet and getting fiber in) to control appetite, its adding RxSugar allulose into your daily diet/routine.

Major thanks to RxSugar for extending the 50% Off Here

Electrolytes & hydration:Low sodium and fluid status activate the renin-angiotensin system, which heightens cravings and perceived hunger. Replenishing electrolytes often calms this false “hunger loop.”

Strategic fasting:Fasting upregulates adiponectin and increases sensitivity of GLP-1 receptors, while transiently lowering ghrelin. The result is a reset in hunger signaling without slowing metabolic rate when done correctly.

Movement timing:Post-meal walking accelerates GLUT4 translocation in muscle, reducing glucose excursions and minimizing the reactive hypoglycemia that drives rebound cravings.

The bottom line: Ozempic is a shortcut, but it doesn’t build a system you can sustain for life. Appetite regulation is a trainable skill. When you stack protein, fiber, hydration, fasting, smart movement — and even tools like allulose — you’re harnessing your body’s own pathways to control cravings, naturally.

It's all about stacking these thing together in order to tackle different angles all at once. That is how you create a sustainable method.

Stay strong,

Thomas