The releasing neurons signal to other neurons to trigger the release of stimulating hormones, which triggers the release of the hormone. The releasing hormone is coming from the brain.
Metabolism is the use of energy for growth, use and repair of tissues and maintenance of function (e.g. brain). It can be increased by increasing the muscle to fat ratio.
The stimulating hormone often comes from the pituitary, which especially triggers the release of stimulating thyroid. Both of these trigger the thyroid to tigger T3 and T4.
When the levels of a hormone are too high, the brain will stop to produce stimulating hormones to stop the Production. It can be supplemented through Kelp and seaweed.
Thyroid can increase the glucose uptake by various tissues especially muscles and bones, which increases bone mineral density (especially important for 30+).