Fructose and Sugar: A Major Mediator of Nonalcoholic Fatty Liver Disease - PMC

mice lacking both fructokinase C and A are protected from fructose-induced fatty liver,

fructose component of sugar and HFCS appears to have a major role in inducing fatty liver by both stimulating de novo lipogenesis and blocking β-fatty acid oxidation. Evidence suggests these effects are due to the unique metabolism of fructose by fructokinase that leads to a fall in ATP with nucleotide turnover and uric acid generation.