The most frequently reported symptoms in this study were pain and neurologic symptoms/conditions. The development of fatigue, chronic widespread pain, and muscle/joint pain are all common to LC, ME/CFS, fibromyalgia and hEDS/HSD (30, 47–49). New onset or worsening chronic pain has a prevalence of 45–70% across multiple studies of LC patients (50). ... See more

Multiple studies have found that a high percentage of LC patients also have ME/CFS (26–30). Craniocervical disease, Arnold Chiari malformations, idiopathic intracranial hypertension, and other spinal structural and flow issues have been associated with ME/CFS, fibromyalgia, and connective tissue disorders previously (35, 53–57). Additionally, an es... See more

For example, people with LC identified to have features of post-exertional malaise, often associated with ME/CFS, can benefit from applying a pacing activity management strategy (28, 146, 147). Other non-pharmacologic interventions beneficial for post-exertional malaise, sensory sensitivity, orthostatic intolerance, and other symptoms may also be e... See more