What primarily differentiates DeSci from other efforts to rethink our research system is its use of blockchain tools. This is similar to how blockchain is disrupting other industries, where web2 models of centralized ownership are being challenged by web3 models of decentralized, shared ownership.

Still in its infancy, DeSci lies at the intersection of two broader trends: 1) efforts within the scientific community to change how research is funded and knowledge is shared, and 2) efforts within the crypto-focused movement to shift ownership and value away from industry intermediaries.